By SYDNEY LUPKIN, ABC News
Two Wisconsin women are in federal court today, alleging that Gardasil caused them to go into early menopause and become infertile, but doctors say such claims aren’t rooted in science.
Madelyne and Olivia Meylor, of Mount Horeb, Wis., claim that the vaccine against cancer-causing human papillomavirus, or HPV, caused primary ovarian failure in both of them. The sisters are 20 and 19 years old, respectively.
“There is nothing about this particular vaccine that would make this at all plausible,” said Dr. Kim Gecsi, who directs the ob/gyn clerkship program at University Hospitals Case Medical Center in Cleveland. “There is nothing hormonal in Gardasil or anything anti-hormonal in Gardasil — nothing that should encourage the body to stop producing ovarian hormones.”
Mainstream doctors are calling the claim that two sisters experienced premature ovarian failure after receiving the HPV vaccine (Gardasil) “bogus”. However, this is not the first time that Gardasil has caused premature ovarian failure.
Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination
+ Author Affiliations
1Department of General Practice, North Bellingen Medical Services, Bellingen, Australia
2Department of Obstetrics and Gynaecology, The University of New South Wales Rural Medical School in Coffs Harbour, Coffs Harbour, Australia
- Correspondence to Dr Deirdre Therese Little, [email protected]
Premature ovarian failure in a well adolescent is a rare event. Its occurrence raises important questions about causation, which may signal other systemic concerns. This patient presented with amenorrhoea after identifying a change from her regular cycle to irregular and scant periods following vaccinations against human papillomavirus. She declined the oral contraceptives initially prescribed for amenorrhoea. The diagnostic tasks were to determine the reason for her secondary amenorrhoea and then to investigate for possible causes of the premature ovarian failure identified. Although the cause is unknown in 90% of cases, the remaining chief identifiable causes of this condition were excluded. Premature ovarian failure was then notified as a possible adverse event following this vaccination. The young woman was counselled regarding preservation of bone density, reproductive implications and relevant follow-up. This event could hold potential implications for population health and prompts further inquiry.
Which begs the question: What did Merck Pharmaceuticals know about Gardasil’s effects on ovaries?
The authors noted that, although the Therapeutic Goods Administration (TGA) of Australia provides data on the histology of rat testes and epididymides in the Australian Public Assessment Report for Human Papillomavirus Quadrivalent Vaccine*, no information is provided for rat ovaries. They sent a Freedom of Information request for “documented rat ovarian histology post-quadrivalent* HPV vaccination that may have been performed by the sponsor and forwarded to the TGA”.
*Note: There is only one “quadrivalent HPV Vaccine”. It’s Gardasil.
Here is their report of this highly significant missing data:
It is not known whether this event of premature ovarian failure is linked to the quadrivalent HPV vaccine. More detailed information concerning rat ovarian hist-ology and ongoing fecundity post-HPV vaccination was sought from the Therapeutic Goods Administration
(TGA). Although the TGA’s Australian Public Assessment Report for Human Papillomavirus Quadrivalent Vaccine, February 2011, does report on the histology of vaccinated rat testes and epididymides, no histological report has been available for vaccinated rat ovaries.
The TGA subsequently agreed to a freedom of information application in the public interest (FOI 001-1112) requesting documented rat ovarian histology post-quadrivalent HPV vaccination that may have been performed by the sponsor and forwarded to the TGA. However, a histological report of the ovaries of vaccinated rats remained unavailable beyond a numbering of the corpora lutea present at postweaning euthanasia following the first litter.
Why did the manufacturer provide information regarding male rat testes, but not for female rat ovaries? This is more than a little shocking. It’s absolutely damning! We must question the sincerity of both the manufacturer, Merck, and the TGA—not to mention questioning other regulatory agencies, such as the US’s FDA and the UK’s MHRA.
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