Truth Frequency Radio
Nov 11, 2013

probiotics-intestinal-homeostasis-microbiotics-antibiotics-truth-frequency-radio-chris-geo-sheree-geo-alternative-media-news-informationby: David Gutierrez, Natural News

One of the ways that probiotic bacteria help maintain intestinal health is by promoting the growth of the cells that line the intestine, according to a study conducted by researchers from Emory University and published in The EMBO Journal.

The researchers examined the activity of bacteria from the genus Lactobacillus in the intestines of mice and Drosophila fruit flies. They found that, even in these very distantly related animals, the same mechanism occurred: upon exposure to Lactobacillus, the epithelial (lining) cells of the intestine produced reactive oxygen species (ROS) which then stimulated the growth of intestinal stem cells and led to the regeneration of the intestinal lining. No ROS production was observed in animals whose intestines were free of Lactobacillus; those animals also had suppressed epithelial cell growth.

The researchers hypothesized that early life forms probably produced ROS for immune signaling and antibiotic functions, but that the function of ROS changed over time as animals and their intestinal flora coevolved.

“It is well-known that mammals live in a homeostatic symbiosis with their gut microbiota and that they influence a wide range of physiological processes. However, the molecular mechanisms of the symbiotic cross-talk in the gut are largely unrecognized,” lead researcher Andrew S. Neish said. “In our study, we have discovered that Lactobacilli can stimulate reactive oxygen species that have regulatory effects on intestinal stem cells, including the activation of proliferation of these cells.”

The findings have significant implications for human health, because they illuminate one mechanism through which probiotic bacteria maintain intestinal homeostasis. Scientists might soon be able to identify new species of probiotic microbes simply by looking for species that trigger certain ROS-mediated reactions.

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